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KMID : 0357520170400020317
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Journal of Radiological Science and Technology
2017 Volume.40 No. 2 p.317 ~ p.322
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Radiation Protection Effect of Selenium on the Rat's Prostate
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Choi Hyung-Seok
Choi Jun-Hyeok
Jung Do-Young
Kim Jang-Oh
Shin Ji-Hye
Kim Joo-Hee
Min Byung-In
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Abstract
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High-tech medical equipment has increased the utilization of radiation in the medical field. As a result, research on radiation protection using natural materials has become an important social issue. Selenium is a natural substance that is highly expressed in prostate known that an essential role in prostate cells. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the prostate tissue w as used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium through changes of blood components, Superoxide Dismutase and histological changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet) in the group irradiated with selenium(p<0.05). the observation of tissue changes selenium is an effective component to increase Superoxide Dismutase activity, and it was confirmed that it has an effect of inhibiting the expression of hypertrophy of prostate by irradiation. Therefore, it is considered that selenium can be utilized as a radioprotective agent by inducing prevention of prostate-related diseases.
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KEYWORD
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Selenium , Prostate , SOD , Antioxidant , Radioprotective agent
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